研究者情報

オバタ　ユミ   OBATA YUMI   小幡由美    所属   医学部医学科 麻酔学    職種   准教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Clinical Utility of Urinary Liver-Type Fatty Acid-Binding Protein Measured via Point-of-Care Testing in Acute Kidney Injury After Transcatheter Aortic Valve Implantation.
掲載誌名	正式名：Nephrology (Carlton, Vic.) 略　 称：Nephrology (Carlton) ISSNコード：13205358/14401797
掲載区分	国外
出版社名	WILEY
巻・号・頁	Accepted頁
著者・共著者	Obata Y, Kamijo-Ikemori A, Shimmi S, Ohata K, Sugaya T, Inoue S.
担当区分	筆頭著者,責任著者
発行年月	2026/03
概要	Aim This study evaluated the clinical usefulness of urinary liver‐type fatty acid‐binding protein (L‐FABP) measured via point‐of‐care testing (POCT) based on immunochromatography for the early prediction of acute kidney injury (AKI) following transcatheter aortic valve implantation (TAVI). Methods This retrospective observational study was conducted at a single‐center university hospital and included 186 patients who underwent TAVI. The onset of AKI was defined according to the Acute Kidney Injury Network classification. Urine samples were collected preoperatively, immediately after surgery, 4 h postoperatively and on postoperative days 1, 2 and 3 to measure urinary L‐FABP using POCT. Results Of the 186 patients who underwent TAVI, 24 (12.9%) developed AKI postoperatively. Patients with AKI exhibited a decreased left ventricular ejection fraction, the co‐occurrence of both hypertension and advanced‐stage chronic kidney disease and a longer hospital stay. During the observational period, patients with AKI were found to have significantly higher urinary L‐FABP levels than those without. Preoperative urinary L‐FABP showed the highest predictive performance for AKI onset, with an area under the receiver operating characteristic curve of 0.74 (cutoff value, 4.24 ng/mL; sensitivity, 0.61; specificity, 0.82; diagnostic accuracy, 0.79). Elevated urinary L‐FABP levels above the cutoff value in the early phase of the perioperative period independently predicted AKI onset after adjusting for ejection fraction and the presence of renal dysfunction in the multivariable logistic regression analysis. Conclusion This study indicated for the first time that urinary L‐FABP levels measured via POCT were independently associated with the development of AKI following TAVI, indicating potential utility for early risk assessment.